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Table 3 Proteins of cytoskeleton and muscle

From: Proteomic study of the brackish water mussel Mytilopsis leucophaeata

Protein

Eucaryote

Function

Localisation

Cytoplasmic actin [Q93129]

Branchiostoma Belcheri (Belcher's lancelet)

Transport track for myosin + support of cell stability (Pollard and Cooper 2009)

Cytoskeleton

Actin, cytoplasmic 1 (β-actin) [P79818]

Oryzias latipes (Japanese medaka)

Idem

Idem

Actin [O16808]

Maietiola destructor (Hessian fly or barley midge)

Cell support + providing trafficking routes for myosin in signal transduction (Pollard and Cooper)

cytoskeleton, microfilaments

Actin, cytoskeletal 1A [P53472]

Strongylocentrotus purpuratus (purple sea urchin)

Idem

Idem

Actin, non-muscle 6.2 [P17126]

Hydra vulgaris (fresh water polyp)

Idem

Idem

Actin-3 [P53457]

Diphyllobothrium dentricum (flatworm)

Idem in metazoan muscle cells actin forms a scaffold in which myosin generates force to support muscle contraction

Idem

Actin-3 [P41113]

Podocoryne carnea (jellyfish)

As for cytoplasmic actin

Idem

Actin-18 [P07828]

Dictyostelium discoideum (amoeba)

Idem

Idem

Actin [O17320]

Crassostrea gigas (Pacific oyster)

Idem

Idem

Actin [P50138]

Puccinia graminis(mould)

Idem

Idem

Actin, clone 205 [P18600]

Artemia sp. (crustacean)

Idem

Idem

Plastin-1 [P19179]

Gallus gallus (chicken)

Actin bundling protein

Cytoskeleton

Spectrin α-chain, non-erythrocytic 1 [P07751]

Gallus gallus

Playing an important role in membrane organisation

Cytoplasm, cytoskeleton and cell cortex

Spectrin β-chain [Q00963]

Drosophila melanogaster (fruit fly)

Spectrin links the actin cytoskeleton to the plasma membrane, thus forming a flexible scaffold in the cell cortex (Djinovic-Carugo et al. 2002)

Plasmalemma + cytoskeleton

Heat shock cognate protein HSP90-β [Q04619]

Gallus gallus (chicken)

Early embryonic development, germ cell maturation, cytoskeletal stabilisation, cellular transformation, signal transduction, long-term cell adaptation (Sreedhar et al. 2004)

Cytoplasm + cytoskeleton (microtubules and actin filaments, Cambiazo et al. 1999)

Radixin [P26043]

Mus musculus (mouse)

Participates in signal transduction and regulates cell migration and intercellular adhesion via Rac 1 (Valderrama et al. 2012)

Linking plasmalemma to actin filaments

Ubiquitin [Q86WD4]

Encephalitozoon cuniculi (protozoan)

Involved in the ubiquitin proteasome pathway (Hegde 2010)

Plasmalemma and cytoskeleton (microtubules) (Murti et al. 1988, Hicke and Dunn 2003)

T-complex protein 1 subunit α [P50157]

Ambystoma mexicanum (axolotl, salamander)

TCP-1 is chaperonin, involved in protein folding, e.g. of actin and tubulin (Souès et al. 2003; Yam et al. 2008)

Nucleus, cytoskeleton (microtubule organising centre) and cytoplasm (Souès et al. 2003)

Tubulin β-chain [P11833]

Paracentrotus lividus (sea urchin)

Mitosis, intracellular vesicle transport (www.buzzle.com/articles/microtubules-function. html)

Part of cytoskeleton: microtubules

Tubulin β-2 chain [P52275]

Caenorhabditis elegans

Part of transport track for ATP-driven vesicle movement or chromosomes in mitosis and meiosis

Cytoskeleton: microtubules

Tubulin α-1A chain [A5A6J1]

Pan troglodytes (chimpanzee)

Involved in supporting the cell shape and transport of vesicles

Idem

Tubulin α-3 chain [P05214]

Mus musculus (house mouse)

cf. Tubulin β-chains

Idem

Myosin-9 [P35579]

Homo sapiens (human)

Cytokinesis: vesicle transport via actin filaments, cell shape, secretion and capping

Cytoskeleton, cell cortex together with actin filaments at lamellipodia and at the leading edge of migrating cells

Elongation factor 1α [P02993]

Artemia salina (brine shrimp)

Promoting the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis

Cytoskeleton (actin filaments) (Liu et al. 1996)

Eucaryotic initiation factor 4A-I [A5A6N4]

Pan troglodytes (chimpanzee)

ATP-dependent RNA helicase, involved in mRNA binding to the ribosome

Cytoskeleton (Ziegler et al. 2012)

Myosin-11 [P10587]

Gallus gallus (chicken)

Involved in contraction

Smooth muscle

Myosin catalytic light chain LC-1 [P05945]

Todarus pacificus (Japanese flying squid = cephalopod)

Is dependent on Ca2+ binding for muscle contraction; in molluscan muscle Ca2+ regulation is associated with myosin rather than with actin

Mantle muscle

Myosin essential adductor muscle light chain [P07290]

Mizuhopecten yessoensis (Yesso scallop, bivalve)

Idem

Idem

Paramyosin [O96064]

Mytilus galloprovincialis (Mediterranean mussel)

Attachment to the substrate

Mytilus anterior byssus retractor paramyosin (thick filaments at the myofibrils)

Adductor muscle actin (precursor) [Q26065]

Placopecten magellanicus (sea scallop)

Involved in muscle contraction

Location is in the name

Actin, muscle (precursor) [P12431]

Strongylocentrotus purpuratus (purple sea urchin)

Is involved in muscle contraction

Idem

Tropomyosin [Q9GZ71]

Haliotis diversicolor (variously coloured abalone)

In association with the troponin complex plays a central role in the Ca2+-dependent regulation of muscle contraction

Idem

α-Actinin, sarcomeric [P18091]

Drosophila melanogaster (fruit fly)

F-actin cross-linking protein, anchoring actin to a variety of intracellular structures. By allowing insertion of thick filaments (myosin) the thin filaments (actin) are led to contraction (Stryer 1995a)

 

Actin, larval muscle [P02574]

Drosophila melanogaster (fruit fly)

Actin, together with myosin, is involved in muscle contraction

 

Myosin heavy chain, striated muscle [P24733]

Argopecten irradians (baby scallop)

Involved in muscle contraction (Nyitray et al. 1991)