Skip to main content

Table 2 Proteins from ER, Golgi network and plasma membrane

From: Proteomic study of the brackish water mussel Mytilopsis leucophaeata





Endoplasmin [O18750]

Oryctolagus cuniculus (rabbit)

Ca2+-binding protein, possibly involved in protein folding (Rowling et al. 1994)


Guanine nucleotide-binding protein subunit β [Q5GIS3]

Pinctada fucata (Japanese pearl oyster)

Cargo transport from trans-Golgi network to plasma membrane

Golgi network and plasmalemma (Irannejad and Wedegaertner 2010)

AP-1 complex, subunit β-1 [O35643]

Mus musculus (mouse)

Subunit of adaptor protein complex-1, involved in protein sorting, mediating the recruitment of clathrin to the membrane and recognition of sorting signals within the cytoplasmic tails of transmembrane cargo molecules

Trans-Golgi network and/or clathrin-coated vesicles (UniProt KB/Swiss- Prot:O35643.2, cf. Robinson and Bonifacino 2001)

Clathrin heavy chain 1 [P11442]

Rattus norvegicus

Involved in cargo sorting (cf. adaptor protein complex-1 of Mus musculus)

Clathrin-coated vesicles at the plasma membrane or trans-Golgi network

α-Amylase [P04745]

Homo sapiens (human)

Formation of maltose, maltotriose and α-dextrin from starch

In oyster (Crassostrea gigas) preferentially in digestive tract (Huvet et al. 2003), RER, Golgi, cisternae, condensing vacuoles, and secretory granules (Geuze et al. 1979)

Glyceraldehyde-3-phosphate dehydrogenase 2 [Q9ESV6]

Rattus norvegicus

Conversion of glyceraldehyde-3P to 1,3-bisphosphoglycerate; + Rab2 and protein kinase Ci driven tubulovesicular recycling of proteins from the Golgi to the ER (Tisdale et al. 2009)

Vesicular tubular clusters

Transitional endoplasmic reticulum ATPase (TERA) [P03974]

Sus scrofa (wild boar)

Involved in fragmentation of Golgi stacks during mitosis and reassembly after mitosis; further is TERA involved in the formation of tER (transitional ER) (UniProt KB/Swiss-Prot information)

Golgi and ER

Guanine nucleotide-binding protein G(o), subunit α [O15976]

Mizuhopecten yessoensis (Yesso scallop)

Major neural signalling GTPase. Reacts on food deprivation (Hofler and Koelle 2011)


Idem G(q), subunit α [P38411]

Lymnaea stagnalis (great pond snail)


Guanine nucleotide-binding protein subunit β-2-like 1, Rack1 = receptor for activated c kinase-1 [Q93134]

Biomphalaria glabrata (blood fluke planorb = gastropod)

Involved in integrin signalling at adhesions, e.g. in a complex with kindlin-3

Plasmalemma (Feng et al. 2012)

Peptidyl-prolyl cis-trans isomerase C (cyclophilin C) [Q08E11]

Bos taurus (cow)

Cyclophilin is a protein folding catalyst

ER (Wang and Heitman 2005)

Actin, cytoplasmic 2 (from fibroblastic and epithelial cells) [A2BDB0]

Xenopus laevis (African clawed frog)

Probably involved in contractile ring formation (Dugina et al. 2009)

Colocalisation with myosin 2a in stress fibres and with VASP (vasodilator-stimulated phosphoprotein) in lamellipodia and focal adhesions (Dugina et al. 2009)

ADP-ribosylation factor 1 (Arf 1) [P36579]

Schizosacharomyces pombe 972 h-

Protein trafficking via COPI or clathrin-coated vesicles from ER to Golgi and plasmalemma

Cis/trans-Golgi and plasmalemma (Chavrier and Goud 1999; D’Souza-Schorey and Chavrier 2006)

Peptidoglycan-associated lipoprotein [P0A138]

Pseudomonas putida KT2440

Presence in bivalves may be due to ingestion by the host (Wood 2011)

Cell outer membrane

Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [Q9YGL9]

Gallus gallus (chicken)

Involved in muscle contraction

Localisation is in the name

Outer membrane porin F [P37726]

Pseudomonas fluorescens

Stabilisation of plasmalemma (multipass membrane protein)

Cell outer membrane (cf. VDAC in C. anguineus, Schuurmans Stekhoven et al. 2012)

Ribulose bisphosphate carboxylase large chain [A1EA16]

Agrostis stolonifera (creeping bent grass)

Ribulose 1,5-bisphosphate + CO2 + H2O → 2 3-P-glycerate + 2H+, and 3-P-glycerate + 2-P-glycolate → ribulose 1,5-bisP + O2

Reactions take place in chloroplasts; presence in mollusks indicates contamination by plants

Glycogen phosphorylase from liver [P06737]

Homo sapiens (human)

Glycogen (n) + Pi↔glucose-1P + glycogen(n-1)

Microsomal fraction (ER or glycogen particles) (Tata 1964, Margolis et al. 1979)

Heat shock 70 kDa protein [P08106]

Gallus gallus (chicken)

Conservation of protein shape and anti-stress protectant (De Maio 1999)

Cytosol, plasma membrane and endosomes + lysosomes (Nylandsted et al. 2004)

Heat shock 70 kDa protein cognate 3 [P29844]

Drosophila melanogaster (fruit fly)

Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER

ER (for additional locations and actions see above)

78 kDa glucose-regulated protein [Q16956]

Aplysia californica (California sea hare = mollusc)

Belongs to the heat shock protein 70 family with function as above


Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit STT3A [P46977]

Homo sapiens (human)

Transfer of a high mannose oligosaccharide to Asn-X-Ser/Thr in nascent polypeptide chains. The complex associates with Sec61 at the channel forming translocon complex for protein translocation across the ER

ER (expressed at high levels in the placenta, liver, muscle, pancreas; low in the brain, lung, and kidney)

Calcium transporting ATPase [P22700]

Drosophila melanogaster (fruit fly)

Reversible Ca2+ transport

Via ER and plasmalemma

Trypsin [P00761]

Sus scrofa (wild boar)

Serine protease

In digestive tract (synthesised in pancreas), localised in plasmalemma (Takeuchi et al. 2000)

Na+/K+-ATPase, α-subunit [P05025]

Torpedo californica (Pacific electric ray)

3Na+/2 K+ exchange


Gelsolin-like protein 1 [Q7JQD3]

Lumbricus terrestris (common earth worm)

Regulator of actin filament assembly and disassembly

Plasma and intracellular membranes, including ER, cortical vesicles and mitochondria, plus short actin filaments adhering to the plasma membrane (Hartwig et al. 1989) renal brush border membranes

Malate dehydrogenase cytoplasmic [Q6PAB3]

Xenopus laevis (African clawed frog)

Oxidation of malate to oxaloacetate; confers selectivity of the nucleic acid-conducting channel in renal brush border membranes (Hanss et al. 2002)

Renal brush border membranes

Guanine nucleotide- binding protein subunit β-1 [P17343]

Caenorhabditis elegans

Involved in Gαβγ activation of phospholipase c activity in a cellular signalling process (Yan et al. 2007)

Localisation not disclosed

Ras-related protein O-Rab1 [P22125]

Discopyge ommata (ocellated electric ray)

Probably involved in vesicular traffic

O-Rab1 was found largely in the synaptic vesicle fraction (Ngsee et al. 1991)

Enolase [O02654]

Loligo pealei (longfin inshore squid)

Conversion of 2-phosphoglycerate ↔ phosphenolpyruvate + H2O

Cytoplasm and plasma membrane of synaptosomes (Ueta et al. 2004)

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [B6IYD3]

Rhodospirillum centenum SW

Catalyses the interconversion of 2-phosphoglycerate and 3-phosphoglycerate


Ras-related protein Rap-1b [A5A6J7]

Pan troglodytes (chimpanzee)

Ca2+ ATPase effector (Lacabaratz-Porret et al. 1998)

Plasmalemma (Marridonneau-Parini and de Gunzburg 1992; Mollinedo et al. 1993)